Amygdalin or Vitamin B17 for Cancer Treatment (Vitamin B17)

Vitamin B17

Amygdalin/Vitamin B17 was first isolated in 1830. In 1845 it was used for cancer in Russia, and again in the 1920s in the United States, but it was considered too poisonous. In the 1950s a reportedly nontoxic, synthetic form was patented for use as a meat preservative, and later marketed as Laetrile for cancer treatment. In 1972, Memorial Sloan-Kettering Cancer Center board member Benno Schmidt convinced the hospital to test laetrile so that he could assure others of its ineffectiveness "with some conviction". However, the respected scientist put in charge of the testing, Kanematsu Sugiura, found that laetrile inhibited the secondary tumors in mice without destroying the primary tumors. He repeated the experiment three times with the same results, and then three more times. In a blinded test, however, he was unable to conclude that laetrile had anticancer activity. His first three experiments were not published because, in the words of Chester Stock, Sugiura's supervisor, "it would have caused all kind of havoc". Nevertheless the results were leaked in 1973, causing a stir. Subsequently laetrile was tested on 14 tumor systems, and a Sloan-Kettering press release concluded that "laetrile showed no beneficial effects". Three other researchers were unable to confirm Sugiura's results, although one of three did confirm Sugiara's results in one of his three studies. Mistakes in the Sloan-Kettering press release were highlighted by a group of laetrile proponents led by Ralph Moss, former public affairs official of Sloan-Kettering hospital, who was fired when he announced his membership in the group. These mistakes were considered inconsequential, but Nicholas Wade in Science noted that "even the appearance of a departure from strict objectivity is unfortunate." The results from these studies were published all together.

Vitamin B17

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Vitamin B17 for Cancer Therapy (Vitamin B17)

Vitamin B17

G. Edward Griffin marshals the evidence that cancer is a deficiency disease – like scurvy or pellagra – aggravated by the lack of an essential food compound in modern man's diet. That substance is Vitamin B17. In its purified form developed for cancer therapy, it is known as Laetrile.

This story is not approved by orthodox medicine. The FDA, the AMA, and The American Cancer Society have labeled it fraud and quackery. Yet the evidence is clear that here, at last, is the final answer to the cancer riddle.

Why has orthodox medicine waged war against this non-drug approach? The author contends that the answer is to be found, not in science, but in politics – and is based upon the hidden economic and power agenda of those who dominate the medical establishment.

With billions of dollars spent each year on research, with other billions taken in on the sale of cancer-related drugs, and with fund-raising at an all-time high, there are now more people making a living from cancer than dying from it. If the solution should be found in a simple vitamin, this gigantic industry could be wiped out over night. The result is that the politics of cancer therapy is more complicated than the science.

Vitamin B17

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Vitamin B17/Amygdalin and Laetrile (Vitamin B17)

Vitamin B17

Amygdalin is sometimes confounded with laevomandelonitrile, also called laetrile for short; however, Amygdalin and Laetrile are different chemical compounds. Laetrile, which was patented in the United States, is a semi-synthetic molecule sharing part of the Amygdalin structure, while the "laetrile" made in Mexico is usually Amygdalin, the natural product obtained from crushed apricot pits, or neoamygdalin.

Though it is sometimes sold as "Vitamin B17", it is not a vitamin. Amygdalin/Laetrile was claimed to be a vitamin by Ernst Krebs, Jr in the hope that if classified as a nutritional supplement it would escape the federal legislation regarding the marketing of drugs. He could also capitalise on the public fad for vitamins at that time.

Vitamin B17

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Chemistry of Vitamin B17 or Amygdalin (Vitamin B17)

Vitamin B17

Vitamin B17 or Amygdalin is extracted from almond or apricot kernel cake by boiling ethanol. Vitamin B17 or Amygdalin is precipitated as white minute crystals on evaporation of the solution and the addition of diethyl ether. Liebig and Wöhler were already able to find three decomposition products of the newly discovered amygdalin: sugar, benzaldehyde, and prussic acid. Later research showed that sulfuric acid decomposes it into d-glucose, benzaldehyde, and prussic acid (hydrogen cyanide); while hydrochloric acid gives mandelic acid, d-glucose, and ammonia.

The decomposition induced by enzymes may occur in two ways. Maltase partially decomposes it, giving d-glucose and mandelic nitrile glucoside, C6H5CH(CN)O•C6H11O5; this compound is isomeric with sambunigrin, a glucoside found by E.E. Bourquelot and Danjou in the berries of the Common Elder, Sambucus nigra. Emulsin, on the other hand, decomposes it into benzaldehyde, cyanide, and two molecules of glucose; this enzyme occurs in the bitter almond, and consequently the seeds invariably contain free cyanide and benzaldehyde. An "amorphous amygdalin" is said to occur in the cherry-laurel. Closely related to these glucosides is dhurrin, C14H17O7N, isolated by W. Dunstan and T. A. Henry from the common sorghum or "great millet," Sorghum vulgare; this substance is decomposed by emulsin or hydrochloric acid into d-glucose, cyanide, and 4-hydroxybenzaldehyde.

Natural Vitamin B17 or Amygdalin has the R configuration at the chiral benzyl center. Under mild basic conditions, this stereogenic center epimerizes; the S epimer is called neoamygdalin.

Vitamin B17

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Introduction of Vitamin B17 or Amygdalin (Vitamin B17)

Vitamin B17

Pierre-Jean Robiquet and A. F. Boutron-Charlard who are responsible introduces Amygdalin in 1803. After that, it was promoted as a cancer cure by Ernst T. Krebs under the name "Vitamin B17", but studies have found it to be ineffective.

Amygdalin or Vitamin B17, C20H27NO11, is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. It also subsequently investigated by Liebig and Wöhler in 1830, and others.

Amygdallin or Vitamin B17 can be found in several other related species in the genus of Prunus, including apricot (Prunus armeniaca) and black cherry (Prunus serotina).

Vitamin B17

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